Our computational analysis of 14,646 single-cell transcriptomes revealed that MDSCs emerge through an aberrant neutrophil maturation trajectory in the spleen that confers them an immunosuppressive cell state. To identify MDSCs in an unbiased manner, we used single-cell RNAseq to compare MDSC-containing splenic myeloid cells from breast tumor-bearing mice to wildtype controls. Here, we sought to determine the molecular features of breast cancer-associated MDSCs using the widely studied mouse model based on mammary tumor virus (MMTV) promoter-driven expression of the polyoma middle T oncoprotein (MMTV-PyMT). It remains elusive how MDSCs differ from their normal myeloid counterparts, which limits our ability to specifically detect and therapeutically target MDSCs during cancer. Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the capacity to suppress adaptive immune responses during cancer.
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